Specifications
Immunogen
a 16 amino acid peptide from near the center of human Integrin alpha 4.
Target
Alternative Names
ITGA4; integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor); IA4; CD49D; integrin alpha-4; 269C wild type; integrin alpha 4; integrin alpha-IV; VLA-4 subunit alpha; integrin alpha-4 subunit; CD49 antigen-like family member D; antigen CD49D
Product Background
Antigen Description
The product of this gene belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an alpha 4 chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Alpha 4 chain associates with either beta 1 chain or beta 7 chain. [provided by RefSeq, Jul 2008]
Pathway
Adaptive Immune System; Arrhythmogenic right ventricular cardiomyopathy; Arrhythmogenic right ventricular cardiomyopathy (ARVC); Cell adhesion molecules (CAMs); Cell surface interactions at the vascular wall; Dilated cardiomyopathy; ECM-receptor interaction; Extracellular matrix organization
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.
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Citations
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Bendall, LJ; Kortlepel, K; et al. Bone marrow fibroblast exposure to the inflammatory cytokines tumor necrosis factor-or and interferon-gamma increases adhesion of acute myeloid leukemia cells and alters the adhesive mechanism. EXPERIMENTAL HEMATOLOGY 25:132-139(1997).
KINASHI, T; STPIERRE, Y; et al. EXPRESSION OF GLYCOPHOSPHATIDYLINOSITOL-ANCHORED AND GLYCOPHOSPHATIDYLINOSITOL-NONANCHORED ISOFORMS OF VASCULAR CELL-ADHESION MOLECULE-1 IN MURINE STROMAL AND ENDOTHELIAL-CELLS. JOURNAL OF LEUKOCYTE BIOLOGY 57:168-173(1995).