Anti-ITGA4; ITGB7 monoclonal antibody, clone SN1160-3H29

Antibody Isotype

IgG2

Clone

SN1160-3H29

Species Reactivity

Mouse

Immunogen

Cell lysates of mouse lymphocytes

Conjugate

Application Notes

IP: 1/100 - 1/400; Flow Cyt: 1/50 - 1/200; IHC-P: 1/100 - 1/200.

Alternative Names

ITGA4; integrin alpha 4; integrin alpha-4; integrin alpha-IV; LPAM subunit alpha; VLA-4 subunit alpha; VLA-4 receptor, alpha 4 subunit; CD49 antigen-like family member D; lymphocyte Peyer patch adhesion molecules subunit alpha; CD49D;

Entrez Gene ID

UniProt ID

Antigen Description

Integrin alpha 4 beta 7, also known as, the lymphocyte Peyers patch adhesion molecule (LPAM1) is a member of the integrin family of cell surface receptors. It is expressed primarily on mucosal lymphocytes, but is also present on NK cells and eosinophils. The alpha 4 beta 7 heterodimer mediates the binding of lymphocytes to its ligand, mucosal vascular addressin (MAdCAM1) on the high endothelial venules, thereby directing the homing of lymphocytes into Peyers patches and intestinal lamina propria.

Pathway

Adaptive Immune System, organism-specific biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; Cell surface interactions at the vascular wall, organism-specific biosystem; Dilated cardiomyopathy, organism-specific biosystem;