IL6R (NP_000556, 21 a.a. ~ 120 a.a) partial recombinant protein with GST tag. The sequence is APRRCPAQEVARGVLTSLPGDSVTLTCPGVEPEDNATVHWVLRKPAAGSHPSRWAGMGRR LLLRSVQLHDSGNYSCYRAGRPAGTVHLLVDVPPEEPQLS
This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.[provided by RefSeq, May 2011]
Pathway
Cytokine Signaling in Immune system; HIF-1 signaling pathway; IL-6 Signaling Pathway; Immune System
Citations
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