Anti-IGF2 monoclonal antibody, clone 620DU25.4.7

Antibody Isotype

IgM

Clone

620DU25.4.7

Species Reactivity

Human

Conjugate

Application Notes

WB: 1:500-8000

Alternative Names

IGF2; Insulin-like growth factor II; Somatomedin-A; Insulin-like growth factor II Ala-25 Del; Preptin

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a member of the insulin family ofpolypeptide growth factors, which are involved in development andgrowth. It is an imprinted gene, expressed only from the paternalallele, and epigenetic changes at this locus are associated withWilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, andSilver-Russell syndrome. A read-through INS-IGF2 gene exists, whose5' region overlaps the INS gene and the 3' region overlaps thisgene. Alternatively spliced transcript variants encoding differentisoforms have been found for this gene.

Pathway

Apoptosis; Cardiac Progenitor Differentiation; Endochondral Ossification; Hedgehog Signaling Pathway; Hemostasis; IGF1R signaling cascade; IRS-related events triggered by IGF1R; Metabolism of proteins;