Anti-ZP3 polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

A region within synthetic peptide: QWSRSASRNR RHVTEEADVT VGPLIFLDRR GDHEVEQWAL PSDTSVVLLG, corresponding to internal sequence amino acids 342-391 of Human ZP3

Conjugate

Unconjugated

Application Notes

WB: 0.6 μg/ml.

Alternative Names

ZP3; zona pellucida glycoprotein 3 (sperm receptor); zona pellucida glycoprotein 3A (sperm receptor) , ZP3A, ZP3B; zona pellucida sperm-binding protein 3; ZP3 372; ZP3 424; HUMZP3; Sperm receptor; zona pellucida glycoprotein 3 (sperm receptor); zona pellu

Entrez Gene ID

7784

UniProt ID

P21754

Antigen Description

The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene is a structural component of the zona pellucida and functions in primary binding and induction of the sperm acrosome reaction. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a C-terminal consensus furin cleavage site, and a transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. A variation in the last exon of this gene has previously served as the basis for an additional ZP3 locus; however, sequence and literature review reveals that there is only one full-length ZP3 locus in the human genome. Another locus encoding a bipartite transcript designated POMZP3 contains a duplication of the last four exons of ZP3, including the above described variation, and maps closely to this gene.

Pathway

Ovarian Infertility Genes, organism-specific biosystem;

We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More