Animals were immunized with particulate murine zonae pellucidae. Spleen cells were fused with Sp2/0 mouse myeloma cells. During development and maturation, mammalian oocytes are surrounded by the zona pellucida, which in the mouse is comprised of three sulfated glycoproteins, ZP1, ZP2 and ZP3. The zona pellucida mediates sperm binding at fertilization, provides a post-fertilization block to polyspermy, and facilitates passage of pre-implantation embryos down the oviduct. The antibody specifically binds to mouse ZP3 glycoprotein (amino acids 336-342). The antibody cross-reacts with rat zonae but not with non-rodent species. Following passive immunization, this antibody completely blocks both in vivo and in vitro fertilization of subsequently ovulated mouse eggs.
Morphology
Lymphoblast
Growth Properties
Suspension
CultureMethod
Storage
Liquid nitrogen vapor phase.
Target
Synonyms
ZP3; zona pellucida glycoprotein 3; zona pellucida sperm-binding protein 3; sperm receptor; zona pellucida protein C; zona pellucida glycoprotein ZP3; Zp-3;
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