Anti-TTR (native) polyclonal antibody [Biotin]

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Full length native Prealbumin (purified from plasma) (Human).

Conjugate

Alternative Names

TTR; transthyretin; PALB,prealbumin, amyloidosis type I; HsT2651; Amyloid polyneuropathy; Amyloidosis I; ATTR; Dysprealbuminemic euthyroidal hyperthyroxinemia; Dystransthyretinemic hyperthyroxinemia; HsT2651; PALB; Prealbumin amyloidosis type I; Prealbumi

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc.

Pathway

Amyloids, organism-specific biosystem; FOXA2 and FOXA3 transcription factor networks, organism-specific biosystem;