Tag/Conjugate
Unconjugated
Alternative Names
Transthyretin; TTR; TBPA; Prealbumin
Concentration
Batch dependent - please inquire should you have specific requirements.
Buffer
20mM PBS, 350mM Nacl, 500mM Imidazole, 10% Glycerol, pH7.2
Preservative
0.05% Proclin300
Storage
2-8 °C (up to 1 Year). Avoid freezing
Introduction
Transthyretin (TTR or TBPA) is a transport protein in the serum and cerebrospinal fluid that carries the thyroid hormone thyroxine (T4) and retinol-binding protein bound to retinol. This is how transthyretin gained its name: transports thyroxine and retinol. The liver secretes transthyretin into the blood, and the choroid plexus secretes TTR into the cerebrospinal fluid.
Citations
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Montecinos, HA; Richter, H; et al. Synthesis of transthyretin by the ependymal cells of the subcommissural organ. CELL AND TISSUE RESEARCH 320:487-499(2005).
ALBERS, KM; DAVIS, FE; et al. EXPRESSION OF AN EPIDERMAL KERATIN PROTEIN IN LIVER OF TRANSGENIC MICE CAUSES STRUCTURAL AND FUNCTIONAL ABNORMALITIES. JOURNAL OF CELL BIOLOGY 128:157-169(1995).