Parathyroid related protein (PTHLH), is a polypeptide hormone produced by almost every tissue of the body and is closely related to parathyroid hormone (PTH). It signals through its receptor, PTHR1, regulating endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. The receptor for this hormone (PTHRP) is responsible for most cases of humoral hypercalcemia of malignancy.
Pathway
Class B/2 (Secretin family receptors); Endochondral Ossification; G alpha (s) signalling events; GPCR downstream signaling; GPCR ligand binding; Signaling by GPCR
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