The original antibody was generated by immunizing a human antibody-producing transgenic mouse with human PTHrP.
Conjugate
Unconjugated
Applications
Application Notes
The original human IgG2 version of this antibody binds parathyroid hormone-related protein with a binding affinity of 0.11 nM. The binding characterization of the human IgG2 version of this antibody towards PTHrP was done using ELISA. Excess PTHrP production causes hypercalcemia, such as tumor-dependent hypercalcemia often caused by PTHrP secreted by tumor cells in large amounts. This human anti-human PTHrP antibody has had a significant suppressive and therapeutic effect on PTHrPinduced hypercalcemia in a malignant hypercalcemia associated with tumor (MAH) model mice.
Target
Alternative Names
PTHLH; PTH-rP; PTHrP; PLP; PTHrP[107-139]; Parathyroid hormone-like protein
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