Anti-HSD3B1 (aa 1-50) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthetic peptide: MTGWSCLVTG AGGFLGQRII RLLVKEKELK EIRVLDKAFG PELREEFSKL, corresponding to N terminal amino acids 1-50 of Human HSD3B1 (NP_000853).

Conjugate

Application Notes

WB: 1 μg/ml; ELISA: 1/62500.

Alternative Names

HSD3B1; hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1; HSD3B, HSDB3; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1; SDR11E1; short chain dehydrogenase/reductase family 11E; member 1; 3 beta-hydroxysteroid

Entrez Gene ID

UniProt ID

Antigen Description

3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. Efficiently catalyzes the transformation of pregnenolone to progesterone, 17-alpha-hydroxypregnenolone to 17-alpha-hydroxyprogesterone, DHEA to 4-androstenedione, dihydrotestosterone to 5-alpha-androstane-3 beta,17 beta-diol, dehydroepiandrosterone to androstenedione and 5-alpha-androstan-3 beta,17 beta-diol to 5-alpha-dihydrotestosterone.

Pathway

Androgen biosynthesis; C19/C18-Steroid hormone biosynthesis, pregnenolone =>androstenedione =>estrone;