Anti-HIV type 1 P24 Monoclonal antibody, Clone A25-3

Antibody Isotype

IgG1

Clone

A25-3

Species Reactivity

HIV

Immunogen

Bacterially expressed, Hexahistidine amino-terminal tagged HIV-1 p24 Gag recombinant protein (clade B, HXB-3 isolate).

Conjugate

Application Notes

ELISA: 0.6 μg/ml -1.2 μg/ml; Western blot: 0.3 μg/ml-0.6 μg/ml; Immunofluorescence assay: 1.2 μg/ml-2.5 μg/ml; Immunoprecipitation assay: 5 μg/ml-10 μg/ml

Alternative Names

Human immunodeficiency virus; HIV; Human immunodeficiency virus 1; Group VI; Retroviridae; Lentivirus; CA; Capsid protein p24; Human immunodeficiency virus type 1 p24; HIV-1 p24; HIV-1 Gag p24; p24

Antigen Description

HIV1 performs highly complex orchestrated tasks during the assembly, budding, maturation and infection stages of the viral replication cycle. During viral assembly, the proteins form membrane associations and self-associations that ultimately result in budding of an immature virion from the infected cell. Gag precursors also function during viral assembly to selectively bind and package two plus strands of genomic RNA. Capsid protein p24 probably forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex. HIV-1 Gag p24 antigen is a capsid protein that constitutes the core of HIV-I. p24 protein is detectable starting from the early stage of AIDS virus infection, for this reason it is an interesting marker for disease progression in infected patients.