HIV type 1 P24, recombinant protein from Baculovirus
HIV-1 p24 Core Recombinant- derived from HIV-1 gene fragment is a 35 kDa gag polyprotein that includes all of the p24 plus additional amino acids of the C-terminus of p17 and the N-terminus of p15. The HIV-1 p24 core is glycosylated with N-linked sugars a
Greater than 90.0% as determined by HPLC analysis and SDS-PAGE.
Sterile filtered colorless clear solution.
10mM Tris pH-8.0, 300mM NaCl and 0.01% Tween-20.
2-8°C short term, -20°C long term
The human immunodeficiency virus (HIV) is a lentivirus (a subgroup of retrovirus) that causes the acquired immunodeficiency syndrome (AIDS), a condition in humans in which progressive failure of the immune system allows life-threatening opportunistic infections and cancers to thrive. Without treatment, average survival time after infection with HIV is estimated to be 9 to 11 years, depending on the HIV subtype. Infection with HIV occurs by the transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk. Within these bodily fluids, HIV is present as both free virus particles and virus within infected immune cells.
HIV1 performs highly complex orchestrated tasks during the assembly, budding, maturation and infection stages of the viral replication cycle. During viral assembly, the proteins form membrane associations and self-associations that ultimately result in budding of an immature virion from the infected cell. Gag precursors also function during viral assembly to selectively bind and package two plus strands of genomic RNA. Capsid protein p24 probably forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex.
HIV P24; Human immunodeficiency virus P24