Anti-HBV Envelope Antigen Monoclonal antibody

Antibody Isotype

IgG

Species Reactivity

HBV

Immunogen

Native HBeAg.

Conjugate

Alternative Names

Anti-HBV Mab; HBeAg; Hepatitis B Virus E Antigen; Mouse Anti-Hepatitis B 'e' Antigen Monoclonal Antibody; HBV; Hepatitis B Virus; HBV; Hepatitis B Virus; Hepatitis B 'e' Antigen; HBeAg; Hepadnaviridae; Orthohepadnavirus; Hepatitis B virus; HBV; HBe antige

Antigen Description

HBeAg is the extracellular form of HBcAg, hence why the presence of both are markers of viral replication, and antibodies to these antigens are markers of a decline in replication.
Multiple protein products can be produced from the same DNA sequence. When "ORF Core" and "Pre C" are translated together, the result is "HBeAg".
Whereas HBcAg is considered "particulate" and it does not circulate in the blood, however it is readily detected in hepatocytes after biopsy. "HBeAg" is considered "nonparticulate" or "secretory".
Both HBeAg and HBcAg are made from the same reading frame, but HBeAg is secreted from cells and accumulates in serum as an immunologically distinct soluble antigen. HBeAg is secreted and found in the serum of patients and serves as a marker of active replication in chronic hepatitis. Although the function of HBeAg is not clearly understood, one study demonstrated that it downregulated Toll-like receptor 2 expression on hepatocytes and monocytes leading to a decrease in cytokine expression. HBeAg is dispensable for replication, as mutant viruses with defects in the pre-C region are both infectious and pathogenic.