May play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure. Essential for meiotic maturation of germinal vesicle-stage oocytes. The somatic type linker histone H1c is rapidly replaced by H1oo in a donor nucleus transplanted into an oocyte. The greater mobility of H1oo as compared to H1c may contribute to this rapid replacement and increased instability of the embryonic chromatin structure. The rapid replacement of H1c with H1oo may play an important role in nuclear remodeling.
Pathway
Activation of DNA fragmentation factor; Apoptosis induced DNA fragmentation; Cellular Senescence; DNA Damage/Telomere Stress Induced Senescence
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More
Citations
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Wade, MG; Kawata, A; et al. Methoxyacetic acid-induced spermatocyte death is associated with histone hyperacetylation in rats. BIOLOGY OF REPRODUCTION 78:822-831(2008).
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COA
Certificate of Analysis
