Anti-H1F0 monoclonal antibody, clone 1.U.71

Antibody Isotype

IgG2a

Clone

1.U.71

Species Reactivity

Cow; Human; Plant

Immunogen

Nuclei from myeloid leukemia biopsy cells.

Conjugate

Application Notes

ICC/IF: 1 μg/ml; IHC-P: 1 μg/ml; ICC: 5 - 20 μg/ml; WB: 1 - 4 μg/ml.

Alternative Names

H1F0; H1 histone family, member 0; H1FV; histone H1.0; H1.0; H1(0); H1 0; H10; histone H1; histone H1(0); H1.0, H1(0), H1-0; MGC5241;

Entrez Gene ID

UniProt ID

Antigen Description

May play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure. Essential for meiotic maturation of germinal vesicle-stage oocytes. The somatic type linker histone H1c is rapidly replaced by H1oo in a donor nucleus transplanted into an oocyte. The greater mobility of H1oo as compared to H1c may contribute to this rapid replacement and increased instability of the embryonic chromatin structure. The rapid replacement of H1c with H1oo may play an important role in nuclear remodeling.

Pathway

Activation of DNA fragmentation factor, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis induced DNA fragmentation, organism-specific biosystem; Apoptotic executionphase, organism-specific biosystem;