Anti-H1F0 monoclonal antibody, clone FQS7647

Antibody Isotype

IgG

Clone

FQS7647

Species Reactivity

Mouse; Rat; Human

Immunogen

Synthetic peptide corresponding to residues near the N terminus of Human Histone H1.0 (UniProt: P07305).

Conjugate

Application Notes

WB: 1/1000 - 1/10000; IHC-P: 1/100 - 1/250; ICC/IF: 1/100 - 1/250.

Alternative Names

H1F0; H1 histone family, member 0; H1FV; histone H1.0; H1.0; H1(0); H1 0; H10; histone H1; histone H1(0); H1.0, H1(0), H1-0; MGC5241;

Entrez Gene ID

UniProt ID

Antigen Description

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. Linker histones are involved in the formation of higher order structure in chromatin and the maintenance of overall chromatin compaction. Histone H1.0 is a linker histone that is widely expressed in many tissues and almost all vertebrates, unlike some other linker histones.

Pathway

Activation of DNA fragmentation factor, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis induced DNA fragmentation, organism-specific biosystem; Apoptotic executionphase, organism-specific biosystem;