Anti-Macrophages monoclonal antibody (DMABT-51930MG)
Mouse anti-Guinea Pig Macrophages monoclonal antibody for IHC, ELISA, FC, IP, WB
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Guinea Pig lymph node stroma
IHC: 0 - 1/10; FCM: Neat - 1/10
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.
Macrophages; Rabbit Macrophage; RAM11; Macrophage
Macrophages are cells produced by the differentiation of monocytes in tissues. Human macrophages are about 21 micrometres (0. 00083 in) in diameter. Monocytes and macrophages are phagocytes. Macrophages function in both non-specific defense (innate immunity) as well as help initiate specific defense mechanisms (adaptive immunity) of vertebrate animals. Their role is to phagocytose (engulf and then digest) cellular debris and pathogens, either as stationary or as mobile cells. They also stimulate lymphocytes and other immune cells to respond to pathogens. They are specialized phagocytic cells that attack foreign substances, infectious Microbes and cancer cells through destruction and ingestion. Macrophages can be identified by specific expression of a number of proteins including CD14, CD11b, F4/80 (mice)/EMR1 (human), Lysozyme M, MAC-1/MAC-3 and CD68 by flow cytometry or immunohistochemical staining. They move by action of Amoeboid movement.
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Markham, NO; Doll, CA; et al. DIPA-family coiled-coils bind conserved isoform-specific head domain of p120-catenin family: potential roles in hydrocephalus and heterotopia. MOLECULAR BIOLOGY OF THE CELL 25:2592-2603(2014).
Yokota, S; Kikuchi, M; et al. Pathogenesis of systemic inflammatory diseases in childhood: "Lessons from clinical trials of anti-cytokine monoclonal antibodies for Kawasaki disease, systemic onset juvenile idiopathic arthritis, and cryopyrin-associated periodic fever syndrome". MODERN RHEUMATOLOGY 25:1-10(2015).
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.