Anti-Macrophages monoclonal antibody (DMABT-51930MG)

Mouse anti-Guinea Pig Macrophages monoclonal antibody for IHC, ELISA, FC, IP, WB Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
NS-2
Species Reactivity
Guinea pig
Immunogen
Guinea Pig lymph node stroma
Conjugate
Unconjugated

Applications


Application Notes
IHC: 0 - 1/10; FCM: Neat - 1/10
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
Macrophages; Rabbit Macrophage; RAM11; Macrophage

Product Background


Antigen Description
Macrophages are cells produced by the differentiation of monocytes in tissues. Human macrophages are about 21 micrometres (0. 00083 in) in diameter. Monocytes and macrophages are phagocytes. Macrophages function in both non-specific defense (innate immunity) as well as help initiate specific defense mechanisms (adaptive immunity) of vertebrate animals. Their role is to phagocytose (engulf and then digest) cellular debris and pathogens, either as stationary or as mobile cells. They also stimulate lymphocytes and other immune cells to respond to pathogens. They are specialized phagocytic cells that attack foreign substances, infectious Microbes and cancer cells through destruction and ingestion. Macrophages can be identified by specific expression of a number of proteins including CD14, CD11b, F4/80 (mice)/EMR1 (human), Lysozyme M, MAC-1/MAC-3 and CD68 by flow cytometry or immunohistochemical staining. They move by action of Amoeboid movement.

Citations


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References


Kigawa, Y; Miyazaki, T; et al. NADPH Oxidase Deficiency Exacerbates Angiotensin II-Induced Abdominal Aortic Aneurysms in Mice. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 34:2413-2420(2014).
Plege-Fleck, A; Lieke, T; et al. Pig to rat cell transplantation: reduced cellular and antibody responses to xenografts overexpressing PD-L1. XENOTRANSPLANTATION 21:533-542(2014).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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