Synthetic phosphopeptide conjugated to KLH, corresponding to amino acids around phosphorylation site of Serine 836 (S-E-Sp-K-R) of Human Glutamate Receptor 1 (AMPA subtype) (NP_000818.2).
Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist.
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