Anti-GRIA1 monoclonal antibody, clone T4662-2

Antibody Isotype

IgG1

Clone

T4662-2

Species Reactivity

Mouse; Rat

Immunogen

Fusion protein corresponding to Rat Glutamate Receptor 1 (AMPA subtype) aa 1-389 (N terminal). within extracellular domainSequence: MPYIFAFFCT GFLGAVVGAN FPNNIQIGGL FPNQQSQEHA AFRFALSQLT EPPKLLPQID IVNISDSFEM TYRFCSQFSK GVYAIFGFYE RRTVNMLTSF CGALHVCFIT PS

Conjugate

Application Notes

WB: 1/1000

Alternative Names

GRIA1; glutamate receptor, ionotropic, AMPA 1; glutamate receptor 1; GluR1; gluR-1; gluR-K1; glutamate receptor A; glutamate receptor subunit GluR1; AMPA-selective glutamate receptor 1; glutamate receptor, ionotropic, AMPA1 (alpha 1); GluA1; gluR-A;

Entrez Gene ID

UniProt ID

Antigen Description

Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist.

Pathway

Amphetamine addiction, organism-specific biosystem; Amphetamine addiction, conserved biosystem; Amyotrophic lateral sclerosis (ALS), organism-specific biosystem; Amyotrophic lateral sclerosis (ALS), conserved biosystem; Dopaminergic synapse, organism-specific biosystem; Dopaminergic synapse, conserved biosystem; Glutamatergic synapse, organism-specific biosystem;