Specifications
Species Reactivity
Mouse; Rat
Immunogen
A synthetic peptide corresponding to amino acids 400-410 at internal region of human GABRG2. The sequence is C-NNATHLQERDE
Applications
Application Notes
ELISA: 1:16000; WB: 1-3 μg/mL. & The optimal working dilution should be determined by the end user.
Target
Alternative Names
GABRG2; gamma-aminobutyric acid (GABA) A receptor, gamma 2; CAE2; ECA2; GEFSP3; gamma-aminobutyric acid receptor subunit gamma-2; GABA(A) receptor, gamma 2; GABA(A) receptor subunit gamma-2;
Product Background
Antigen Description
This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammlian brain, where it acts at GABA-A receptors, which are ligand-gated chloride channels. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene have been associated with epilepsy and febrile seizures. Multiple transcript variants encoding different isoforms have been identified for this gene.
Pathway
GABA A receptor activation; GABAergic synapse; Ion channel transport; Morphine addiction
Citations
Publication ()
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COA
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