Anti-Fibrinogen polyclonal antibody

There is increasing demand for effective and efficient lightweight structures because of global environmental and resource sustainability concerns. Adhesive bonding has been adopted in many assembly arrangements because of its relative reduction of stress concentration in joints compared to mechanical fasteners. Functionally graded bonded joints presents even greater potentials for reduction of stress concentrations and the tailoring of stress distribution as may be desired in an adhesive layer. This capability provides opportunity for the design of high performance tailored structural assemblies. Although some encouraging analysis and experimental work have been carried out on the development of functionally graded joints, its wide application is still to be realised. This paper reviews the work that has been carried out so far on the method, in terms of analysis, fabrication, experimental testing and application. It also reflects on outstanding issues that need to be resolved in order for wider application to be feasible.

Congenital dysfibrinogenemia is a genetic coagulopathy that leads to compromised fibrinogen function. This case report describes a 26-year-old pregnant woman at the 38th week of gestation who presented with mild gingival bleeding and constant bruising on her joints. As part of her laboratory workup, fibrinogen was found to be significantly decreased and thrombin time was prolonged. Using whole exome DNA sequence analysis, a heterozygous mutation was identified in the fibrinogen ff (FGA) (c.104G > A; p.R35H) gene. This mutation has been reported previously in congenital dysfibrinogenemia (CD) patients who are usually asymptomatic and lack any obvious thrombotic complications. However, both post-partum disseminated intravascular coagulation and mild bleeding have been observed in this type of mutant. The patient in our case received fibrinogen concentrate as replacement therapy during her cesarean section to prevent severe bleeding. Neither major bleeding nor a thrombotic event was observed throughout her surgery.