High affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system.
Pathway
Class A/1 (Rhodopsin-like receptors); Formyl peptide receptors bind formyl peptides and many other ligands; G alpha (i) signalling events; GPCR downstream signaling; GPCR ligand binding; GPCRs, Class A Rhodopsin-like; Neuroactive ligand-receptor interacti
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