Full length protein corresponding to Human FGF19 aa 1-216.Sequence: MRSGCVVVHVWILAGLWLAVAGRPLAFSDAGPHVHYGWGDPIRLRHLYTS GPHGLSSCFLRIRADGVVDCARGQSAHSLLEIKAVALRTVAIKGVHSVRY LCMGADGKMQGLLQYSEEDCAFEEEIRPDGYNVYRSEKHRLPVSLSSAKQ RQLYKNRGFLPLSHFLPMLPMVPEEPEDLRGHLE
Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB.
Pathway
Downstream signaling of activated FGFR; FGF signaling pathway; FGFR ligand binding and activation; FGFR4 ligand binding and activation; FRS2-mediated cascade; IRS-mediated signalling; IRS-related events
Citations
Publication ()
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