Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB.
Pathway
Downstream signaling of activated FGFR; FGF signaling pathway; FGFR ligand binding and activation; FGFR4 ligand binding and activation; FRS2-mediated cascade; IRS-mediated signalling; IRS-related events
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More
Citations
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Pai, R; Dunlap, D; et al. Inhibition of fibroblast growth factor 19 reduces tumor growth by modulating beta-catenin signaling. CANCER RESEARCH 68:5086-5095(2008).
Sawey, ET; Chanrion, M; et al. Identification of a Therapeutic Strategy Targeting Amplified FGF19 in Liver Cancer by Oncogenomic Screening. CANCER CELL 19:347-358(2011).
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COA
Certificate of Analysis
