Specificity
Expressed in fetal brain, cartilage, retina, and adult gall bladder.
Tag/Conjugate
Unconjugated
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. Information available upon request.
Antigen Description
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This growth factor is a high affinity, heparin dependent ligand for FGFR4. Expression of this gene was detected only in fetal but not adult brain tissue. Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required for initiation of inner ear development. [provided by RefSeq, Jul 2008]
Function
fibroblast growth factor receptor binding; growth factor activity; protein binding;
Synonyms
FGF19; fibroblast growth factor 19; FGF-19;
Citations
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Desnoyers, L; Pai, R; et al. Targeting FGF19 inhibits tumor growth in colon cancer xenograft and FGF19 transgenic hepatocellular carcinoma models. ONCOGENE 27:85-97(2008).
Song, KH; Li, TG; et al. Bile Acids Activate Fibroblast Growth Factor 19 Signaling in Human Hepatocytes to Inhibit Cholesterol 7 alpha-Hydroxylase Gene Expression. HEPATOLOGY 49:297-305(2009).