Recombinant fragment corresponding to Human Emi1 aa 272-438. BC018905.Sequence: INVSKVSTTWKKILEDDKGAFQLYSKAIQRVTENNNKFSPHASTREYVMF RTPLASVQKS AAQTSLKKDAQTKLSNQGDQKGSTYSRHNEFSEVAKTLKKNESLKACIRC NSPAKYDCYL QRATCKREGCGFDYCTKCLCNYHTTKDCSDGKLLKASCKIGPLPGTK Dat
Conjugate
Unconjugated
Applications
Application Notes
WB: 1/200 - 1/1000;
Target
Alternative Names
FBXO5; F-box protein 5; EMI1; FBX5; Fbxo31; F-box only protein 5; F-box protein Fbx5; early mitotic inhibitor 1;
Regulates progression through early mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Binds to the APC activators CDC20 and FZR1/CDH1 to prevent APC activation. Can also bind directly to the APC to inhibit substrate-binding.
Pathway
APC/C-mediated degradation of cell cycle proteins; Cell Cycle, Mitotic; G1/S Transition; M Phase
Citations
Publication ()
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COA
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