Anti-FBXO5 (aa 358-446) polyclonal antibody

Species Reactivity

Human

Immunogen

FBXO5 (NP_036309, 358 a.a. ~ 446 a.a) partial recombinant protein with GST tag. The sequence is RHNEFSEVAKTLKKNESLKACIRCNSPAKYDCYLQRATCKREGCGFDYCTKCLCNYHTTK DCSDGKLLKASCKIGPLPGTKKSKKNLRR

Conjugate

Alternative Names

FBXO5; F-box protein 5; EMI1; FBX5; Fbxo31; F-box only protein 5; F-box protein Fbx5; early mitotic inhibitor 1;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is similar to xenopus early mitotic inhibitor-1 (Emi1), which is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex. Alternatively spliced transcript variants encoding different isoforms have been identified.

Pathway

APC/C-mediated degradation of cell cycle proteins; Cell Cycle, Mitotic; G1/S Transition; M Phase