Specifications
Species Reactivity
Mouse; Rat; Human
Immunogen
Recombinant fragment within Human Emi1 aa 100-250. The exact sequence is proprietary.Database link: Q9UKT4
Applications
Application Notes
Flow Cyt: 1/180; ICC/IF: 1/250; WB: 1/1000 - 1/10000; IHC-P: 1/100 - 1/250.
Target
Alternative Names
FBXO5; F-box protein 5; F box only protein 5; F-box only protein 5; EMI1; FBX5; Fbxo31; F-box protein Fbx5; early mitotic inhibitor 1;
Product Background
Antigen Description
Regulates progression through early mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Binds to the APC activators CDC20 and FZR1/CDH1 to prevent APC activation. Can also bind directly to the APC to inhibit substrate-binding.
Pathway
APC/C-mediated degradation of cell cycle proteins, organism-specific biosystem; Cell Cycle, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; DNA Replication, organism-specific biosystem; E2F mediated regulation of DNA replication, organism-specific biosystem; G1/S Transition, organism-specific biosystem; G1/S-Specific Transcription, organism-specific biosystem;
Citations
Publication ()
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COA
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