Anti-F9 (aa 96-190) polyclonal antibody

Species Reactivity

Human

Immunogen

F9 (NP_000124, 96 a.a. ~ 190 a.a) partial recombinant protein with GST tag. The sequence is QCESNPCLNGGSCKDDINSYECWCPFGFEGKNCELDVTCNIKNGRCEQFCKNSADNKVVC SCTEGYRLAENQKSCEPAVPFPCGRVSVSQTSKLT

Conjugate

Alternative Names

F9; coagulation factor IX; FIX; P19; PTC; HEMB; THPH8; F9 p22; FIX F9; factor 9; factor IX F9; Christmas factor; plasma thromboplastic component; plasma thromboplastin component;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes vitamin K-dependent coagulation factor IX that circulates in the blood as an inactive zymogen. This factor is converted to an active form by factor XIa, which excises the activation peptide and thus generates a heavy chain and a light chain held together by one or more disulfide bonds. The role of this activated factor IX in the blood coagulation cascade is to activate factor X to its active form through interactions with Ca+2 ions, membrane phospholipids, and factor VIII. Alterations of this gene, including point mutations, insertions and deletions, cause factor IX deficiency, which is a recessive X-linked disorder, also called hemophilia B or Christmas disease.

Pathway

Blood Clotting Cascade; Complement and coagulation cascades; Formation of Fibrin Clot (Clotting Cascade); Gamma-carboxylation, transport, and amino-terminal cleavage of proteins