Mouse Anti-Human F9 Gla domain Monoclonal antibody, clone MAAG737

Antibody Isotype

IgG2a

Clone

MAAG737

Species Reactivity

Human; Rat

Immunogen

human FIX

Conjugate

Application Notes

ELISA, IB, Inhibition
ELISA: Binds immobilized human and rat FIX and human FIXa only in the presence of calcium
Immunoblotting: Western blot detects human FIX and light chain of human FIXa under reduced conditions in presence of calcium.
Inhibition: Prolongs plasma clot time in aPTT clotting assay.
Recommended working dilution: Approximately 1-5 μg/ml. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded

Alternative Names

F9; coagulation factor IX; Christmas disease; Factor IX; FIX; hemophilia B; plasma thromboplastic component; F9 p22; FIX F9; factor 9; factor IX F9; serine protease; Christmas factor; plasma thromboplastin component; P19; PTC; HEMB; THPH8; MGC129641; MGC1

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes vitamin K-dependent coagulation factor IX that circulates in the blood as an inactive zymogen. This factor is converted to an active form by factor XIa, which excises the activation peptide and thus generates a heavy chain and a light chain held together by one or more disulfide bonds.

Pathway

Blood Clotting Cascade, organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Extrinsic Pathway, organism-specific biosystem; Formation of Fibrin Clot (Clotting Cascade), organism-specific biosystem; Gamma-carboxylation of protein precursors, organism-specific biosystem;