Recombinant fragment corresponding to Human Junctional Adhesion Molecule 1 aa 30-238. Extracellular domain.Sequence: TVHSSEPEVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKI TASYEDRV TFLPTGITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLI VLVPPSKPTVNIPSSATIGN RAVLTCSEQDGSPPSE
Seems to plays a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Involved in platelet activation. In case of orthoreovirus infection, serves as receptor for the virus.
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