Anti-F11R monoclonal antibody, clone 7F22

Antibody Isotype

IgG1

Clone

7F22

Species Reactivity

Human

Immunogen

Recombinant full length Human Junctional Adhesion Molecule 1 produced in HEK293T cells (NP_653087).

Conjugate

Application Notes

WB: 1/4000; ICC/IF: 1/100;

Alternative Names

F11R; F11 receptor; JAM1, junctional adhesion molecule 1; junctional adhesion molecule A; CD321; JAM 1; JAM A; JAMA; JCAM; PAM 1; platelet F11 receptor; platelet adhesion molecule 1; junctional adhesion molecule 1; JAM; KAT; JAM1; PAM-1;

Entrez Gene ID

UniProt ID

Antigen Description

Seems to plays a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Involved in platelet activation. In case of orthoreovirus infection, serves as receptor for the virus.

Pathway

Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; Cell junction organization, organism-specific biosystem; Cell surface interactions at the vascular wall, organism-specific biosystem; Cell-Cell communication, organism-specific biosystem; Cell-cell junction organization, organism-specific biosystem; Epithelial cell signaling in Helicobacter pylori infection, organism-specific biosystem;