EXOSC3 is a component of the exosome 3->5 exoribonuclease complex, a complex that degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3 untranslated regions. It is required for the 3processing of the 7S pre-RNA to the mature 5.8S rRNA. Has a 3-5 exonuclease activity. [Swiss-Prot]
Pathway
Activation of Genes by ATF4, organism-specific biosystem; Deadenylation-dependent mRNA decay, organism-specific biosystem; Destabilization of mRNA by Butyrate Response Factor 1 (BRF1), organism-specific biosystem; Destabilization of mRNA by KSRP, organism-specific biosystem; Destabilization of mRNA by Tristetraprolin (TTP), organism-specific biosystem; Diabetes pathways, organism-specific biosystem; Disease, organism-specific biosystem;
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