Anti-ENPEP (internal region) polyclonal antibody

Pakistan is facing multiple challenges for harnessing the indigenous energy resources and devise rational energy policies. The country is believed to have abundant energy resources, however, coping substantial electricity supply gap of over 5000 MW. This paper analyses country's energy and power planning studies conducted since its independence in 1947 and policies announced so far. It is found that water resources management attained more emphasis in early decades of post-independence rather than energy concerns. The first energy and power planning study was conducted in late 1960s and since then various studies were undertaken to supplement five yearly medium term development plans of government. However, it is pertinent to mention that formal energy and power policies were only announced from 1994 onwards owing to growing electricity demand and progressing industrialization. Beside this, the focus of these policies is not only varied but were conceived without undertaking integrated energy planning using energy modeling tools e.g. MARKAL/TIMES; LEAP, ENPEP BALANCE, MESSAGE and EnergyPLAN. It is despite the fact that these tools are successfully applied globally for devising the energy policies and address the complexities of energy system by assisting effective policy formulation. This study recommends that integrated energy planning using energy modeling tools will be helpful to develop sustainable energy policies in Pakistan to eradicate electricity crises.

Non-alcoholic fatty liver disease (NAFLD) affects 25% of the population and can progress to cirrhosis with limited treatment options. As the liver secretes most of the blood plasma proteins, liver disease may affect the plasma proteome. Plasma proteome profiling of 48 patients with and without cirrhosis or NAFLD revealed six statistically significantly changing proteins (ALDOB, APOM, LGALS3BP, PIGR, VTN, and AFM), two of which are already linked to liver disease. Polymeric immunoglobulin receptor (PICR) was significantly elevated in both cohorts by 170% in NAFLD and 298% in cirrhosis and was further validated in mouse models. Furthermore, a global correlation map of clinical and proteomic data strongly associated DPP4, ANPEP, TGFBI, PIGR, and APOE with NAFLD and cirrhosis. The prominent diabetic drug target DPP4 is an aminopeptidase like ANPEP, ENPEP, and LAP3, all of which are up-regulated in the human or mouse data. Furthermore, ANPEP and TGFBI have potential roles in extracellular matrix remodeling in fibrosis. Thus, plasma proteome profiling can identify potential biomarkers and drug targets in liver disease.