Mouse anti-Human EIF4A3 polyclonal antibody

Species Reactivity

Human

Immunogen

DDX48 (NP_055555, 312 a.a. ~ 411 a.a) partial recombinant protein with GST tag. The sequence is PQKERESIMKEFRSGASRVLISTDVWARGLDVPQVSLIINYDLPNNRELYIHRIGRSGRY GRKGVAINFVKNDDIRILRDIEQYYSTQIDEMPMNVADLI

Conjugate

Alternative Names

EIF4A3; eukaryotic translation initiation factor 4A3; RCPS; DDX48; MUK34; NUK34; NMP265; eIF4AIII; eukaryotic initiation factor 4A-III; NMP 265; hNMP 265; eIF4A-III; eIF-4A-III; DEAD box protein 48; nuclear matrix protein 265; ATP-dependent RNA helicase D

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a nuclear matrix protein. Its amino acid sequence is highly similar to the amino acid sequences of the translation initiation factors eIF4AI and eIF4AII, two other members of the DEAD box protein family.

Pathway

Antiviral mechanism by IFN-stimulated genes; Deadenylation of mRNA; Exon junction complex (EJC); Gene Expression