Specifications
Immunogen
Synthetic peptide within Human EIF3S3 aa 69-99 (N terminal) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.Database link: O15372
Applications
Application Notes
WB: 1/100 - 1/500; IHC-P: 1/10 - 1/50;
Target
Alternative Names
EIF3H; eukaryotic translation initiation factor 3, subunit H; EIF3S3; eIF3-p40; eIF3-gamma; eukaryotic translation initiation factor 3 subunit H; eIF-3-gamma; eIF3 p40 subunit; eukaryotic translation initiation factor 3 subunit 3; eukaryotic translation i
Product Background
Antigen Description
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.
Pathway
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S; Eukaryotic Translation Initiation; Formation of the ternary complex, and subsequently, the 43S complex; Gene Expression
Citations
Publication ()
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COA
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