Anti-eIF3H monoclonal antibody

Antibody Isotype

IgG2a

Species Reactivity

Human

Immunogen

Recombinant fragment with tag: YDPIKTAQGS LSLKAYRLTP KLMEVCKEKD FSPEALKKAN ITFEYMFEEV PIVIKNSHLI NVLMWELEKK SAVADKHELL SLASSNHLGK NLQLLMDRV, corresponding to amino acids 152-251 of Human EIF3S3

Conjugate

Alternative Names

EIF3H; eukaryotic translation initiation factor 3, subunit H; EIF3S3, eukaryotic translation initiation factor 3, subunit 3 gamma, 40kDa; eukaryotic translation initiation factor 3 subunit H; eIF3 gamma; eIF3 p40; eIF3h; eIF-3-gamma; eIF3 p40 subunit; eu

Entrez Gene ID

UniProt ID

Antigen Description

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.

Pathway

Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, organism-specific biosystem; Cap-dependent Translation Initiation, organism-specific biosystem; Eukaryotic Translation Initiation, organism-specific biosystem; Formation of a pool of free 40S subunits, organism-specific biosystem; Formation of the ternary complex, and subsequently, the 43S complex, organism-specific biosystem; GTP hydrolysis and joining of the 60S ribosomal subunit, organism-specific biosystem; Gene Expression, organism-specific biosystem;