Anti-eIF3H monoclonal antibody (DMABT-H18627)

Mouse anti-eIF3H monoclonal antibody for WB Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
22I6
Species Reactivity
N/A
Conjugate
Unconjugated

Applications


Application Notes
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1.0 to 2.0 μg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
EIF3H; eukaryotic translation initiation factor 3, subunit H; EIF3S3, eukaryotic translation initiation factor 3, subunit4gamma, 40kDa; eukaryotic translation initiation factor4subunit H; eIF3 gamma; eIF3 p40
Entrez Gene ID
UniProt ID

Product Background


Antigen Description
The elF3H (eIF3-p40) is a subunit of eukaryotic translation initiation factor4(eIF3) complex that plays a central role in the protein translation initiation. The eIF3 consists of at least 10 subunits ranging from 35 to280kd. elF3-p40 is constitutively expressed in many tissues, including spleen thymus, prostate, colon, ovary, etc. Eukaryotic translation initiation factor 3 subunit H is a protein that in humans is encoded by the EIF3H gene. 0The function about eIF3H antigen include protein binding; contributes_to translation initiation factor activity; contributes_to translation initiation factor activity.
Pathway
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, organism-specific biosystem; Cap-dependent Translation Initiation, organism-specific biosystem; Eukaryotic Translation Initiation, organism-specific biosystem; Formation of a pool of free 4S subunits, organism-specific biosystem; Formation of the ternary complex, and subsequently, the 43S complex, organism-specific biosystem; GTP hydrolysis and joining of the 6S ribosomal subunit, organism-s.

Citations


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References


LoVerde, PT; Osman, A; et al. Schistosoma mansoni: TGF-beta signaling pathways. EXPERIMENTAL PARASITOLOGY 117:304-317(2007).
Daxinger, L; Oey, H; et al. A Forward Genetic Screen Identifies Eukaryotic Translation Initiation Factor 3, Subunit H (eIF3h), as an Enhancer of Variegation in the Mouse. G3-GENES GENOMES GENETICS 2:1393-1396(2012).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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