A synthetic peptide of human EDEM3 is used for rabbit immunization.
Conjugate
Unconjugated
Target
Alternative Names
EDEM3; ER degradation enhancer, mannosidase alpha-like 3; C1orf22; ER degradation-enhancing alpha-mannosidase-like protein 3; alpha-1,2-mannosidase EDEM3; ER degradation-enhancing alpha-mannosidase-like 3; ER degradation-enhancing -mannosidase-like protei
Quality control in the endoplasmic reticulum (ER) ensures that only properly folded proteins are retained in the cell through recognition and degradation of misfolded or unassembled proteins. EDEM3 belongs to a group of proteins that accelerate degradation of misfolded glycoproteins in the ER (Hirao et al., 2006 [PubMed 16431915]).[supplied by OMIM, Mar 2008]
Pathway
Asparagine N-linked glycosylation; Calnexin/calreticulin cycle; ER Quality Control Compartment (ERQC); Metabolism of proteins; N-glycan trimming in the ER and Calnexin/Calreticulin cycle; Post-translational protein modification;Protein processing in endoplasmic reticulum;
Citations
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