Anti-DYNC1I2 monoclonal antibody, clone 85.2

Antibody Isotype

IgG2b

Clone

85.2

Species Reactivity

Mouse; Rat; Sheep; Cow; Xenopus laevis; Fruit fly; Fish

Immunogen

Native cytoplasmic dynein from Cow brain.

Conjugate

Application Notes

WB: 1/1000 - 1/5000; IHC-Fr: 1/10 - 1/100;

Alternative Names

DYNC1I2; dynein, cytoplasmic 1, intermediate chain 2; cytoplasmic dynein 1 intermediate chain 2; DH IC-2; dynein intermediate chain 2, cytosolic; cytoplasmic dynein intermediate chain 2; MGC140044;

Entrez Gene ID

UniProt ID

Antigen Description

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes.

Pathway

Phagosome, organism-specific biosystem; Phagosome, conserved biosystem; Salmonella infection, organism-specific biosystem; Salmonella infection, conserved biosystem; Vasopressin-regulated water reabsorption, organism-specific biosystem; Vasopressin-regulated water reabsorption, conserved biosystem.