Specifications
Immunogen
Recombinant protein fragment, corresponding to a region within amino acids 129 and 376 of Human DYNC1I2
Applications
Application Notes
WB: 1/500 - 1/3000.
Target
Alternative Names
DYNC1I2; dynein, cytoplasmic 1, intermediate chain 2; DNCI2, dynein, cytoplasmic, intermediate polypeptide 2; cytoplasmic dynein 1 intermediate chain 2; DH IC-2; dynein intermediate chain 2, cytosolic; cytoplasmic dynein intermediate chain 2; dynein, cyto
Product Background
Antigen Description
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes.
Pathway
Cell Cycle; Cell Cycle, Mitotic; Centrosome maturation; G2/M Transition; Loss of Nlp from mitotic centrosomes; Loss of proteins required for interphase microtubule organization??from the centrosome; Mitotic G2-G2/M phases
Citations
Publication ()
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COA
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