Anti-DYNC1I2 monoclonal antibody, clone FQS22353

Antibody Isotype

IgG

Clone

FQS22353

Species Reactivity

Mouse; Rat; Human

Immunogen

Recombinant fragment corresponding to Human DYNC1I2.

Conjugate

Application Notes

WB: 1/1000 - 1/10000; IHC-P: 1/50 - 1/100; IP: 1/10 - 1/100;

Alternative Names

DYNC1I2; dynein, cytoplasmic 1, intermediate chain 2; DNCI2, dynein, cytoplasmic, intermediate polypeptide 2; cytoplasmic dynein 1 intermediate chain 2; DH IC-2; dynein intermediate chain 2, cytosolic; cytoplasmic dynein intermediate chain 2; dynein, cyt

Entrez Gene ID

UniProt ID

Antigen Description

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes.

Pathway

Cell Cycle, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; Centrosome maturation, organism-specific biosystem; G2/M Transition, organism-specific biosystem; Loss of Nlp from mitotic centrosomes, organism-specific biosystem; Loss of proteins required for interphase microtubule organization??from the centrosome, organism-specific biosystem; Mitotic G2-G2/M phases, organism-specific biosystem;