General Notes
This product (Catalog No. DPABH-26464) is a rabbit-derived polyclonal antibody raised against human DIO3. This antibody exhibits cross-reactivity with DIO3 from mouse, rat, and monkey. It has been affinity purified by Protein A. Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development.
DPABH-26464 is suitable for use in WB 1 (1000-3000), IHC 1 (50-1:200) applications.
DPABH-26464 is supplied as a liquid formulation in Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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