Anti-DIO3 (aa 250-300) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Mouse; Rat

Immunogen

A synthetic peptide corresponding to amino acids 250-300 of rat Dio3.

Conjugate

Application Notes

WB: 0.5 μg/mL. & The optimal working dilution should be determined by the end user.

Alternative Names

DIO3; deiodinase, iodothyronine, type III; 5DIII; DIOIII; type III iodothyronine deiodinase; type 3 DI; type-III 5-deiodinase; deiodinase, iodothyronine, type 3;

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this intronless gene belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3,5-triiodothyronine (T3) to inactive metabolites, 3,3,5-triiodothyronine (RT3) and 3,3-diiodothyronine (T2), respectively. This enzyme is highly expressed in the pregnant uterus, placenta, fetal and neonatal tissues, suggesting that it plays an essential role in the regulation of thyroid hormone inactivation during embryological development. It contains a selenocysteine (Sec) residue, which is essential for efficient enzyme activity. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3 UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal.

Pathway

Selenium metabolism Selenoproteins;