Anti-DIO3 monoclonal antibody (DCABH-11283) Made to order

Rabbit anti-Human DIO3 monoclonal antibody for WB, ELISA

View other DIO3 antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human DIO3 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
DIO3; deiodinase, iodothyronine, type III; TXDI3; type III iodothyronine deiodinase; type 3 DI; type-III 5 deiodinase
Entrez Gene ID
UniProt ID

Product Background


Gene summary
DIO3 (Deiodinase, Iodothyronine, Type III) is a Protein Coding gene. Diseases associated with DIO3 include hemangioma and neonatal thyrotoxicosis. Among its related pathways are Metabolism and Viral mRNA Translation. GO annotations related to this gene include thyroxine 5-deiodinase activity and thyroxine 5-deiodinase activity. An important paralog of this gene is DIO1. The protein encoded by this intronless gene belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3',5-triiodothyronine (T3) to inactive metabolites, 3,3',5'-triiodothyronine (RT3) and 3,3'-diiodothyronine (T2), respectively. This enzyme is highly expressed in the pregnant uterus, placenta, fetal and neonatal tissues, suggesting that it plays an essential role in the regulation of thyroid hormone inactivation during embryological development. This protein contains a selenocysteine (Sec) residue, which is essential for efficient enzyme activity. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal.
Antigen Description
The protein encoded by this intronless gene belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3,5-triiodothyronine (T3) to inactive metabolites, 3,3,5-triiodothyronine (RT3) and 3,3-diiodothyronine (T2), respectively. This enzyme is highly expressed in the pregnant uterus, placenta, fetal and neonatal tissues, suggesting that it plays an essential role in the regulation of thyroid hormone inactivation during embryological development. This protein contains a selenocysteine (Sec) residue, which is essential for efficient enzyme activity. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3 UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Responsible for the deiodination of T4 (3,5,3,5-tetraiodothyronine) into RT3 (3,3,5-triiodothyronine) and of T3 (3,5,3-triiodothyronine) into T2 (3,3-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development. The function about DIO3 antigen include thyroxine 5-deiodinase activity; thyroxine 5-deiodinase activity.
Pathway
Amine-derived hormones, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of amino acids and derivatives, organism-specific biosystem; Regulation of thyroid hormone activity, organism-specific biosystem; Selenium Metabolism and Selenoproteins, organism-specific biosystem; Selenium Pathway, organism-specific biosystem; Thyroxine biosynthesis, organism-specific biosystem.

Citations


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References


Romitti, M; Wajner, SM; et al. Increased Type 3 Deiodinase Expression in Papillary Thyroid Carcinoma. THYROID 22:897-904(2012).
Singh, SP; Dhakshinamoorthy, R; et al. The thyroxine inactivating gene, type III deiodinase, suppresses multiple signaling centers in Dictyostelium discoideum. DEVELOPMENTAL BIOLOGY 396:256-268(2014).

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