Anti-DIO3 monoclonal antibody Made to order

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

A synthetic peptide of human DIO3 is used for rabbit immunization.

Conjugate

Alternative Names

DIO3; deiodinase, iodothyronine, type III; TXDI3; type III iodothyronine deiodinase; type 3 DI; type-III 5 deiodinase; type-III 5-deiodinase; type 3 iodothyronine selenodeiodinase; iodothyronine deiodinase, placental type; thyroxine deiodinase type III (s

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this intronless gene belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3,5-triiodothyronine (T3) to inactive metabolites, 3,3,5-triiodothyronine (RT3) and 3,3-diiodothyronine (T2), respectively. This enzyme is highly expressed in the pregnant uterus, placenta, fetal and neonatal tissues, suggesting that it plays an essential role in the regulation of thyroid hormone inactivation during embryological development. This protein contains a selenocysteine (Sec) residue, which is essential for efficient enzyme activity. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3 UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal.

Pathway

Amine-derived hormones, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of amino acids and derivatives, organism-specific biosystem; Regulation of thyroid hormone activity, organism-specific biosystem; Selenium Metabolism and Selenoproteins, organism-specific biosystem; Selenium Pathway, organism-specific biosystem; Thyroxine biosynthesis, organism-specific biosystem.