A synthetic peptide corresponding to internal region of human DNMT3A. The sequence is C-DKNATKAGDDEPEY
Conjugate
Unconjugated
Applications
Application Notes
ELISA: 1:32000; WB: 0.5-2 μg/mL. & The optimal working dilution should be determined by the end user.
Target
Alternative Names
DNMT3A; DNA (cytosine-5-)-methyltransferase 3 alpha; DNMT3A2; M.HsaIIIA; DNA (cytosine-5)-methyltransferase 3A; DNA MTase HsaIIIA; DNA cytosine methyltransferase 3A2;
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms.
Pathway
Cysteine and methionine metabolism; Gene Expression; MicroRNAs in cancer; PRC2 methylates histones and DNA
Citations
Publication ()
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COA
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