Synthetic peptide conjugated to KLH derived from within residues 350 - 450 of Human Dnmt3a, phosphorylated at S390 and phosphorylated at S393.
Conjugate
Unconjugated
Applications
Application Notes
ICC/IF: 5 μg/ml; WB: 1 μg/ml
Target
Alternative Names
DNMT3A; DNA (cytosine-5-)-methyltransferase 3 alpha; DNMT3A2; M.HsaIIIA; DNA (cytosine-5)-methyltransferase 3A; DNA MTase HsaIIIA; DNA cytosine methyltransferase 3A2;
Required for genome wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZNF238. Can actively repress transcription through the recruitment of HDAC activity.
Pathway
Cysteine and methionine metabolism; Epigenetic regulation of gene expression; Methionine degradation; MicroRNAs in cancer
Citations
Publication ()
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COA
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