Specifications
Species Reactivity
Rat; Human
Immunogen
Recombinant fragment within Human CYP26A1. The exact sequence is proprietary.Database link: O43174
Applications
Application Notes
WB: 1/1000 - 1/10000; IHC-P: 1/250 - 1/500.
Target
Alternative Names
CYP26A1; cytochrome P450, family 26, subfamily A, polypeptide 1; cytochrome P450, subfamily XXVIA, polypeptide 1; cytochrome P450 26A1; CP26; CYP26; P450RAI; P450RAI1; hP450RAI; cytochrome P450RAI; retinoic acid 4-hydroxylase; P450, retinoic acid-inactiva
Product Background
Antigen Description
Plays a key role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA. Capable of both 4-hydroxylation and 18-hydroxylation. Responsible for generation of several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA and 18-OH-RA.
Pathway
Adipogenesis, organism-specific biosystem; Biological oxidations, organism-specific biosystem; Cytochrome P450 - arranged by substrate type, organism-specific biosystem; Metabolism, organism-specific biosystem; Nuclear receptors in lipid metabolism and toxicity, organism-specific biosystem; Phase 1 - Functionalization of compounds, organism-specific biosystem; Retinol metabolism, organism-specific biosystem;
Citations
Publication ()
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COA
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