Specifications
Species Reactivity
Mouse; Human
Immunogen
Synthetic peptide within Human Cytochrome P450 1A2 aa 262-290 (internal sequence) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.Database link: P05177
Applications
Application Notes
ICC/IF: 1/10 - 1/50; IHC-P: 1/10 - 1/50; WB: 1/1000;
Target
Alternative Names
CYP1A2; cytochrome P450, family 1, subfamily A, polypeptide 2; CP12; P3-450; P450(PA); cytochrome P450 1A2; CYPIA2; P450 form 4; cytochrome P450 4; cytochrome P(3)450; cytochrome P450-P3; dioxin-inducible P3-450; microsomal monooxygenase; xenobiotic monoo
Product Background
Antigen Description
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N3-demethylation. Also acts in the metabolism of aflatoxin B1 and acetaminophen. Participates in the bioactivation of carcinogenic aromatic and heterocyclic amines. Catalizes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin.
Pathway
Aflatoxin B1 metabolism; Arachidonic acid metabolism; Arylamine metabolism; Caffeine metabolism
Citations
Publication ()
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COA
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